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Life's Blood Table of Contents: Class Notes ANTIGLOBULIN TESTING. Executive assault mods. The antiglobulin test, which is also referred to as the anti-human globulin test (AHG) or the Coombs test, is the cornerstone of detecting clinically significant unexpected antibodies that have coated cells either in vivo or in vitro.
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WarningThrombosis.Thrombosis may occur with immune globulin preparations. (See Thrombosis under Cautions.).Risk factors for thrombosis may include advanced age, prolonged immobilization, hypercoagulable disorders, history of venous or arterial thrombosis, use of estrogen-containing preparations, indwelling central vascular catheters, hyperviscosity, and other cardiovascular risk factors. Thrombosis may occur in the absence of known risk factors.In patients at risk of thrombosis, administer immune globulin using minimum dose and minimum infusion rate practicable and ensure adequate hydration before administration of the drug. Monitor for signs and symptoms of thrombosis; assess blood viscosity in those at risk for hyperviscosity.Renal Dysfunction and Acute Renal Failure.Renal dysfunction, acute renal failure, osmotic nephrosis, and death may occur with immune globulin preparations. (See Renal Effects under Cautions.).Patients predisposed or at increased risk of renal dysfunction include those with any degree of preexisting renal insufficiency, diabetes mellitus, age 65 years, volume depletion, sepsis, paraproteinemia, or concomitant therapy with nephrotoxic drugs.Renal dysfunction and acute renal failure occur more commonly in patients receiving IGIV preparations containing sucrose.In patients at risk of renal dysfunction or failure, administer immune globulin using minimum dose and minimum infusion rate practicable.Introduction. CompatibleDextrose 5% in waterActions.Provides a broad spectrum of opsonic and neutralizing IgG antibodies against a wide variety of bacterial and viral agents.IgG antibodies contained in immune globulin provide passive immunity by increasing an individual’s antibody titer and antigen-antibody reaction potential and prevent or modify certain infectious diseases in susceptible individuals.Mechanism of action in the treatment of primary humoral immunodeficiency not fully elucidated.Mechanism by which IGIV increases platelet counts in the treatment of ITP not fully elucidated. May saturate Fc (crystallizable fragment) receptors on cells of the reticuloendothelial system, resulting in decreased Fc-mediated phagocytosis of antibody-coated cells.
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